Assessment of antiplatelet activity of 2-aminopyrimidines

A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.

A series of 4,6-diaryl-2-aminopyrimidines 14a–q was assessed for in vitro antiplatelet activity. Except for 14(e, f, h & i), all compounds are more potent than aspirin with 14k (X = 4′–OCH3; Y = 2″,4″-diCl) twice as potent.Figure optionsDownload as PowerPoint slideHighlights
► A series of diaryl heterocycle, 2-aminopyrimidine was synthesized and evaluated as antiplatelet agent.
► Compound 14k is found to be two times more potent than aspirin.
► These encouraging results will be helpful for the development of new antiplatelet compounds.