کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394620 1501174 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation
چکیده انگلیسی

A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ionizable function). The built model was able to correctly predict the activity of known ACE inhibitors. The model was then used as query to search 3D databases of peptides. Three novel peptides (I, II and III) were synthesized and biologically evaluated in vitro. It appears that the in vitro activity of peptides I, II and III was consistent with their molecular modeling results. Our results provided confidence for the utility of the pharmacophore model to retrieve novel ACE inhibitory peptides with desired biological activity by virtual screening.

3D pharmacophore model for ACE inhibitory peptides was generated.Figure optionsDownload as PowerPoint slideHighlights
► A validated 3D pharmacophore model was generated for ACE inhibitory peptides.
► The pharmacophore model was able to correctly predict the activity of known ACE inhibitors.
► The pharmacophore model can be used to retrieve novel ACE inhibitory peptides with desired biological activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 8, August 2011, Pages 3428–3433
نویسندگان
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