Synthesis of an antitumor active endoperoxide from 11-keto-β-boswellic acid

An endoperoxide was synthesized starting from 11-keto-β-boswellic acid and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The compound induces apoptosis and shows an average IC50 value of 0.4–4.5 μM.

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