کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1394985 | 1501192 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)2(maip)](ClO4)2 (2a) and [Ru(bpy)2(paip)](ClO4)2 (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).
Two new ruthenium (II) complexes [Ru(bpy)2(maip)]2+ (2a) and [Ru(bpy)2(paip)]2+ (2b) have been synthesized and characterized. Their DNA-binding, cytotoxcity and antioxidant activity against hydroxyl radical have been studied.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 564–571
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 564–571
نویسندگان
Yun-Jun Liu, Cheng-Hui Zeng, Hong-Liang Huang, Li-Xin He, Fu-Hai Wu,