کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395040 1501200 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone
چکیده انگلیسی

A novel chromone Schiff base, 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone (L) and its Ln(III) complexes (Ln = La, Eu) were synthesized and characterized. The crystal structure of the La(III) complex was determined by single-crystal X-ray diffraction: crystallized in the orthorhombic system, space group Pbcn, Z = 8, a = 14.595(2) Å, b = 20.055(3) Å, c = 30.078(5) Å, R1 = 0.0657. Fluorescence titration spectra, electronic absorption titration spectra, EB displacement and viscosity measurement indicated that both the ligand and the complexes can bind to DNA via the intercalation mode, and that the binding affinity of the La(III) complex is higher than that of the Eu(III) complex and of the ligand (L). The antioxidant activity experiments show that these compounds also exhibit good antioxidant activities against OH and O2−. Moreover, the Eu(III) complex exhibits characteristic fluorescence of europium ion in different organic solvents.

A novel Schiff base ligand, 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone, and its La(III) and Eu(III) complexes were synthesized and their DNA-binding abilities, antioxidant activities and fluorescence properties were investigated in detail.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 6, June 2009, Pages 2425–2433
نویسندگان
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