Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase

• Novel FMDP derivatives were synthesized.
• Antimicrobial activity of FMDP amides was evaluated.
• Primary amide of FMDP was the most active compound.
• Docking studies of the FMDP derivatives have been performed.

Novel FMDP amides 4–6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from C. albicans.

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