Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II

A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds were found to be moderate active against Mycobacterium tuberculosis. Correlation of structure–biological activity has been done.

Synthesis, structure and in vitro antituberculosis activity of some new pyridazine derivatives are described.Figure optionsDownload as PowerPoint slide