کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396331 | 1501183 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to find the exact cytotoxic mechanism of these 3-aryl-1-isoquinolinamines, we analyzed the cell cycle dynamics by flow cytometry and found that 3-aryl-1-isoquinolinamine 6k-treated HeLa cells were arrested in G2/M phase, which is related to apoptosis.
Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 5493–5497
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 5493–5497
نویسندگان
Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Eung-Seok Lee, Young Bok Lee, Chang-Ho Ahn, Won-Jea Cho,