Synthesis and antitumor activity of new shikonin glycosides

Eleven shikonin glycosides were synthesized and evaluated for their antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug sensitive cell lines (K562, MCF-7 and HL60) and their drug resistant cell sublines (K562/ADR, MCF-7/ADR and HL60/ADR).

Eleven shikonin glycosides were synthesized and evaluated for there antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug-sensitive and drug-resistant cell lines.Figure optionsDownload as PowerPoint slide