Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cu (II), Ni (II) and Co (II) complexes

M(II) complexes of the type [HLCu2Cl3], [HLCu2(O(CO)CH3)3], [HLM2Cl4(H2O)3] and [HLM2(OC(O)CH3)4(H2O)3], where M = Ni(II), Co(II) have been synthesized by condensation of 3-acyl-2-one indol and hydrazinecarbothioamide (2:1) in the presence of divalent metal salt in methanolic medium. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometries of the metal centers are either distorted octahedral, or square planer. These metal complexes were also tested for their antibacterial and antifungal activities to assess their inhibiting potential.

Schiff base M (II) complexes were synthesized and evaluated for antimicrobial activity. Complex 4 [HLNi2(OC(O)CH3)4(H2O)3] exhibited best antimicrobial activity.Figure optionsDownload as PowerPoint slide