کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1396425 1501187 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a new anti-diabetic agent by combining VOSO4 and vitamin E in a single molecule: Studies on its spectral, thermal and pharmacological properties
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of a new anti-diabetic agent by combining VOSO4 and vitamin E in a single molecule: Studies on its spectral, thermal and pharmacological properties
چکیده انگلیسی

Vanadium(IV) complex of vitamin E (Vit E) ligand was reported. In this complex, binuclear ligand acts as a monodentate via oxygen of phenolic group. The vanadyl(II) ion is surrounded by two molecules of Vit E and two water molecules. The [VO(Vit E)2(H2O)2]2H2O complex was isolated by the reaction between VOSO4 and vitamin E in ethanol/water solvent (50/50 w/w) at pH = 8. The solid vanadyl(II) complex has been characterized by elemental analyses (CHN), photometric titrations, infrared spectra, molar conductivity, electronic spectra, TGA/DSC, SEM and XRD studies. Electronic and magnetic measurements are confirmed that the speculated geometry of vanadyl(II) complex is square pyramidal geometry. The microbial test was performed for the vanadyl complex against some kinds of bacteria and fungi. The [VO(Vit E)2(H2O)2]2H2O complex was proved effective in addressing diabetic of type I in case of experimental animal than other compounds were prepared in the literature.

Structure of [VO(Vit E)2(H2O)2]2H2O complex.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 7, July 2010, Pages 3070–3079
نویسندگان
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