Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones

The fluoroquinolones are an important family of synthetic antimicrobial agents being clinically used over the past thirty years. In addition, some fluoroquinolones have been used in the development of anticancer drugs, and others have demonstrated anti-HIV activity. Furthermore, there has been some additional work investigating the effect of metal ions on biological activity.Aiming to obtain novel palladium(II) and platinum(II) complexes that exhibit biological activity, we have synthesized complexes using fluoroquinolones (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, and gatifloxacin) as ligands. The compounds were characterized using IR and NMR spectroscopy, thermogravimetric and elemental analyses.The complexes show activity against Mycobacterium tuberculosis strain H37Rv. The minimal inhibitory concentration (MIC) of the complexes was determined.

Palladium complexes with fluoroquinolone antibiotics were obtained. Metal coordination to biologically active molecules can be used as a strategy to enhance activity and overcome resistance. The compounds present antitubercular activity.Figure optionsDownload as PowerPoint slide