کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396817 | 1501199 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents](/preview/png/1396817.png)
چکیده انگلیسی
Two series of novel 1,5-benzothiazepine derivatives (23 compounds) were efficiently synthesized and evaluated for antibacterial and antifungal activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compound 2e exhibited the greatest antimicrobial activity. Preliminary study of the structure–activity relationship revealed that substituents in phenyl rings had a great effect on the antimicrobial activity of these compounds.
Synthesis and biological evaluation of novel 1,5-benzothiazepine derivatives are reported in this paper. Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 7, July 2009, Pages 2815–2821
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 7, July 2009, Pages 2815–2821
نویسندگان
Lanzhi Wang, Ping Zhang, Xuemei Zhang, Yonghong Zhang, Yuan Li, Yongxiang Wang,