کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1396904 1501207 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and testing of peptides for anti-prion activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and testing of peptides for anti-prion activity
چکیده انگلیسی

Creutzfeldt–Jakob disease (CJD) is one of the fatal transmissible spongiform encephalopathies for which there is no known cure. The disease is associated with an abnormally folded prion protein, PrP-res, which is thought to form due to interaction between normal prion PrPC and PrP-res. Small peptides were designed to prevent this interaction. A structure–activity relationship is described for a series of peptides which were synthesised and tested for their activity against two prion disease model assays, an in vitro cellular assay and an in vitro anti-aggregation polymerisation assay. A number of peptides were found to be active at levels of 100 μM. New libraries were synthesised in order to concentrate on discovering new, shorter peptides which could be leads for developing peptidomimetics.

This paper describes the design, synthesis and evaluation of small peptides designed to interfere with interaction between PrP-res and PrPSc.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 11, November 2008, Pages 2418–2427
نویسندگان
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