کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397394 1501160 2012 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oncoepigenomics: Making histone lysine methylation count
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Oncoepigenomics: Making histone lysine methylation count
چکیده انگلیسی

Increasing studies show that methylation of histone lysine residues is implicated in the development and progression of varying disease states such as schizophrenia, diabetes, and multiple human cancers. Targeting the specific enzymes responsible for these processes has fueled global investigation into the understanding and correction of epigenetic pathology. This review aims to assemble a timely account of the current progress against chromatin-modifying histone lysine methyltransferases (KMTs) and demethylases (KDMs) to inform ongoing and future efforts into this promising field. In particular, we report on their role in tumor growth and progression and the development of small molecules that modulate these enzymes.

This review reports on the state of histone lysine methyltransferases and demethylases in tumor growth and the development of small molecules that modulate these enzymes.Figure optionsDownload as PowerPoint slideHighlights
► Epigenetic enzymes are therapeutic targets for cancer drug development.
► Histone lysine methyltransferase and demethylase enzymes are implicated in multiple cancer types.
► Several classes of natural products and small molecules have been developed to target these enzymes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 56, October 2012, Pages 179–194
نویسندگان
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