Transition metal complexes of 2, 6-di ((phenazonyl-4-imino) methyl)-4-methylphenol: Structure and biological evaluation

A symmetric ligand 2, 6-di ((phenazonyl-4-imino)methyl)-4-methylphenol (Dpmp) and its cobalt dinuclear complex (Co2(Dpmp)2(NO3)2(H2O)2·NO3·EtOH, (1) and zinc mononuclear complex Zn(Dpmp)(NO3)2, (2) have been prepared. The crystal structures were determined by single-crystal X-ray diffraction. The biological activity has been evaluated by examining their anti-oxidative activity and ability to bind to bovine serum albumin (BSA) and calf-thymus DNA (CT DNA) with UV–vis absorption, fluorescence, viscosity measurements and circular dichroism (CD) spectroscopies. The complexes exhibit good binding propensity to BSA and CT DNA. Both 1 and 2 have been found to promote cleavage of pUC19 DNA in the absence of any reducing agent. Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals.

The ligand 2, 6-di ((phenazonly-4-imino)methyl)-4-methylphenol and its complexes have been synthesized. Their biological activity has been evaluated. They have been found to promote cleavage of pUC19 DNA and have anti-oxidative activity.Figure optionsDownload as PowerPoint slideHighlights
► Crystal structures of dinuclear and mononuclear complexes of a symmetric ligand have been determined.
► Binding behavior of the complexes with BSA and DNA was investigated under simulated physiologic conditions.
► Antioxidant tests in vitro show the compounds possess significant antioxidant activity.