کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397574 | 1501178 | 2011 | 10 صفحه PDF | دانلود رایگان |
In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect.
A series of xanthones have been synthesized and evaluated their antioxidant and cytotoxic activities. The enhancement of reactive oxygen species in NTUB1 cells was observed.Figure optionsDownload as PowerPoint slideResearch highlights
► A series of xanthone derivatives were synthesized.
► Several synthetic xanthones identified as XO inhibitor and revealed ABTS·+ scavenging activity.
► 2 and 8 induced an accumulation of NTUB1 in the G1 phase arrest and apoptosis by the increase of ROS level.
► The combination of cisplatin and antioxidant 2 enhanced the cell death in NTUB1 cells.
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 4, April 2011, Pages 1222–1231