Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives

► Compound 1 was isolated from Aspergillus sp. as the innate immunosuppressor. ► Compound 1 and its derivatives were synthesized and evaluated. ► The amide-containing derivatives showed much potent activities than those of 1. ► Compounds 21b, 21d, 37 and 43 suppressed the production levels of IL-8 in HUVECs.