کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1397663 | 1501184 | 2010 | 6 صفحه PDF | دانلود رایگان |
Six transition metal compounds of Schiff base ligands were evaluated for the inhibitory activity on jack bean urease, of which compounds 2–6 were determined by single crystal X-ray analysis. It was found that copper(II) complexes 1 and 4 showed strong inhibitory activity against jack bean urease (IC50 = 0.52 and 0.46 μM), compared with acetohydroxamic acid (IC50 = 42.12 μM) as a positive reference. Cobalt(II), nickel(II) and zinc(II) compounds also exhibited potent inhibitory activity (IC50 = 3.88–25.20 μM). A docking analysis using the AUTODOCK 4.0 program could explain the inhibitory activities of 1 and 4 against urease.
Schiff base transition metal compounds 1–6 were evaluated for the inhibitory activities on the jack bean urease (IC50 = 0.46–25.20 μM). A docking analysis using the AUTODOCK 4.0 program could explain the inhibitory activities of compound 1 and 4 against urease.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 10, October 2010, Pages 4473–4478