کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1397824 | 1501191 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy](/preview/png/1397824.png)
Synthesis of glycosyl derivatives of hydroxyanthraquinones (6–10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as substances with the ability of dissolving crystalline calcium oxalate. In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic.
Newly synthesized glycosyl derivatives of hydroxyanthraquinones have shown good properties as substances potentially useful in kidney stone therapy. Tests were performed on calcium oxalate and on real kidney stones in ex vivo test. Tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 3, March 2010, Pages 1001–1007