کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397901 1501194 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines
چکیده انگلیسی

Novel bis-cyclen derivative A with urea, mono-cyclen derivative B with urea and amino acid urea C were synthesized as DNA cleavage agents. The structures of these new compounds were identified by MS and 1H NMR spectroscopy. The catalytic activities on DNA cleavage of these compounds were subsequently studied, and results show that A is a much better catalyst in DNA cleavage process than that of B and C. The effects of reaction time and catalyst concentration were also investigated. The results indicate that A can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) to nicked DNA under physiological conditions with high yields (nearly 100%) via a hydrolytic mechanism.

Bis-cyclen derivative A with urea can catalyze the DNA cleavage under physiological conditions to produce nicked DNA with high yields (nearly 100%) via a hydrolytic mechanism, in the absence of exogenous agents.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 12, December 2009, Pages 5090–5093
نویسندگان
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