کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1398025 1501205 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel symmetry bis-enediynes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of novel symmetry bis-enediynes
چکیده انگلیسی

A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI50 = 0.04 μM) and HL-60 (GI50 = 0.09 μM) cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration.

Bis-enediyne 1g showed most potent growth inhibition activity against all tumor cell lines in low concentration, blocked cell cycle via controlling Cyclin A and Cyclin B expressions and induced apoptosis phenomenon in high concentration.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 35–41
نویسندگان
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