کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1398028 | 1501205 | 2009 | 7 صفحه PDF | دانلود رایگان |
Novel derivatives of 4,5-substituted-1,2,4-triazole-thiones and 2,5-substituted-1,3,4-thiadiazoles were synthesized and evaluated for their cytotoxicity. The biological study indicated that compounds 4-ethyl-5-(4,5,6,7-tetrahydro-1-benzothien-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 13, N-ethyl-5-(4,5,6,7-tetrahydro-1-benzothien-2-yl)-1,3,4-thiadiazol-2-amine 16, 4-amino-5-(4,5,6,7-tetrahydro-1-benzothien-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 20 and 4-amino-5-(5-phenylthien-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 21 possessed high cytotoxicity in vitro against thymocytes. The corresponding IC50 values were 0.46 μM, 5.2 × 10−6 μM, 0.012 μM and 1.0 × 10−6 μM. Most toxic against lymphocytes was compound 21, IC50 – 0.012 μM. The tested compounds showed a general stimulation effect on B-cells' response.
Novel derivatives of 4,5-substituted-1,2,4-triazole-3-thiones and 2,5-substituted-1,3,4-thiadiazoles were synthesized and evaluated for their cytotoxicity. High cytotoxicity was ascertained in test in vitro against thymocytes and lymphocytes and a general stimulating effect on B-cells' response.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 63–69