کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1398037 1501205 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: Synthesis, cytostatic and antiviral activity evaluations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: Synthesis, cytostatic and antiviral activity evaluations
چکیده انگلیسی

The target phosphoramidates 5a–e were prepared in one step from 3-hydroxypropyl derivatives 3a–e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a–e and 5a–e were evaluated for their cytostatic and antiviral activity against malignant tumour cell lines and normal human fibroblasts (WI 38). All phosphoramidate derivatives 5a–e possess significantly greater inhibitory activities than the corresponding 3-hydroxypropyl derivatives 3a–e, whereby compound 5a showed the most potent inhibitory activities against cervical, pancreatic and colon carcinoma cell lines (IC50 = 5 − 7 μM).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 143–151
نویسندگان
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