کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1398193 1501219 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
چکیده انگلیسی

New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into consideration is the nuclear PPAR-γ whose crystallographic structure is available on the PDB database as 2PRG. Thus the hypoglycemic and hypolipidemic activities of compounds were compared with the result of their docking after removal of the co-crystallized ligand present in the 2PRG structure. Molecular modeling studies were carried out using the Autodock 3.0.5 and ADT 1.1 programs.

New arylidene-thiazolidinediones were synthesized and evaluated (hypoglycemic and hypolipidemic activities). The molecular targets used for docking were PPAR-α and γ, and the molecular origins of the biological activities were discussed in terms of binding energies, using rosiglitazone as the reference crystallographic ligand.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 10, October 2007, Pages 1263–1271
نویسندگان
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