Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones

• Benzothiazole hydrazones were synthesized.
• Antiproliferative activity of these compounds was evaluated.
• Compounds 3n and 3o showed significant cytotoxicity against leukemia (HL-60).
• Compounds 3o and 3p exhibited cytotoxicity against three cancer cell lines.
• Benzothiazole hydrazones bear hydroxyl groups may have a good oral biodisponibility.

Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.

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