Discovery of coumarin–monastrol hybrid as potential antibreast tumor-specific agent

Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin–monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.

A novel series of coumarin–monastrol hybrids were synthesized and evaluated for their in vitro anticancer activity, the compound 10 exhibited selective and potent antibreast cancer activity.Figure optionsDownload as PowerPoint slideHighlights
► Discovery of coumarin–monastrol hybrids with antibreast cancer activity.
► Compound 10 inhibits the proliferation of both primary and metastatic breast cancer cells.
► Compound 10 induces apoptosis in breast cancer cells and arrests cell cycle at G1 phase.