کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399295 | 1501156 | 2013 | 7 صفحه PDF | دانلود رایگان |

Chemical investigation of stem bark of Crataeva nurvala afforded 5,7-dimethoxy-3-phenyl-1-ethyl-1,4-dihydro-4-quinolone and a steroidal glycoside with unprecedented pentacyclic ring system named crataemine (1a) and crataenoside (2) respectively. The structures of the compounds were determined by spectroscopic analysis. A series of compounds with modification at position 1 of 1a (1a–1c) were prepared. All compounds were screened for cytotoxic activity against HeLa, PC-3 and MCF-7 cells. Only 1a and 2 showed potency against all three cells. Mechanism based study for activity of the compounds demonstrated that it could block the migration of more aggressive HeLa and PC-3 cells and prevent their colony formation ability as well. The compounds potentiated apoptosis in HeLa and PC-3 cells in a significant manner.
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► A new quinolone alkaloid and pentacyclic steroidal glycoside from Crataeva nurvala.
► Demonstrated cytotoxic activity against HeLa, PC-3 and MCF-7 cell lines.
► Prevented colony formation ability of HeLa and PC-3 cells.
► Potentiated apoptosis in a significant manner
Journal: European Journal of Medicinal Chemistry - Volume 60, February 2013, Pages 490–496