Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties

► Dimeric 3,5-bis(benzylidene)-4-piperidones 1 are a novel class of potent cytotoxic agents. ► Demonstrate noteworthy tumour-selective toxicities compared to a number of normal cells. ► Mode of action includes apoptosis, PARP cleavage and G2/M phase blockage of the cell cycle. ► Potent multidrug-resistant reversal agents.