Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives

A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide–hydrazone derivatives 3a–l were less active than pyrazinamide. In contrast, the N4-ethyl-N1-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H37Rv (IC90 = 16.87 μg/mL). Details of the structure–activity and structure–cytotoxicity relationships are discussed.

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