کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399594 | 1501190 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives](/preview/png/1399594.png)
چکیده انگلیسی
Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives have been prepared by cyclocondensation of ethyl 2-cyano-3,3-bis(methylthio)prop-2-enoate with 2-amino-4-(substitutedphenyl)thiazole to give 3-cyano-2-methylthio-4-oxo-4H-6-(substitutedphenyl)thiazolo[3,2-a]pyrimidin (2a–j) and further reacting with hydrazine hydrate to yield the target compounds (3a–j). The chemical structure of the compounds was confirmed by IR and 1H NMR spectral data. All the compounds of the series have been screened for their antibacterial and antifungal activity studies. The result revealed that all compounds showed significant antimicrobial activity.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1635–1638
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1635–1638
نویسندگان
Chandrahas N. Khobragade, Ragini G. Bodade, Shankaraiah G. Konda, Bhaskar S. Dawane, Anand V. Manwar,