کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399602 | 1501190 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The first glucuronide prodrug of the hedgehog signaling inhibitor cyclopamine was synthesized. The carbamoyl derivatisation of cyclopamine significantly decreased its toxicity towards the U87 human glioblastoma cell line. However, when the prodrug was incubated with β-glucuronidase in the culture media, the active drug was efficiently released thereby restoring its anti-proliferative activity.
The glucuronide prodrug 1 of the hedgehog signaling inhibitor cyclopamine was synthesized and evaluated as a potential selective antitumor agent for the treatment of glioblastoma.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1678–1682
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1678–1682
نویسندگان
Florian Hamon, Brigitte Renoux, Corinne Chadéneau, Jean-Marc Muller, Sébastien Papot,