Keywords: سیکلوپامین; Cerebral cortical neuron; Excitatory/inhibitory balance; Induced pluripotent stem cell; Microelectrode array; Synchronized burst; BMI; bicuculline methiodide; Cont; control; Cyc; cyclopamine; ESC; embryonic stem cell; Exc; excitatory-rich population; IBI;
مقالات ISI سیکلوپامین (ترجمه نشده)
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Keywords: سیکلوپامین; Cementoblast; Differentiation; Hedgehog; Purmorphamine; Cyclopamine; Bone morphogenetic protein;
Keywords: سیکلوپامین; Sonic Hedgehog; Retina; Regeneration; Müller glia; Zebrafish; Cyclopamine;
Keywords: سیکلوپامین; Cyclopamine; Tumor extracellular matrix; Nanotherapeutics; Pancreatic cancer; Hedgehog signaling pathway;
Keywords: سیکلوپامین; Biotransformation; Cunninghamella echinulata; Cyclopamine; Cyclopamine congeners;
Keywords: سیکلوپامین; TAK-441 (PubChem CID: 44187367); Vismodegib (PubChem CID: 24776445); Cyclopamine (PubChem CID: 442972)Smoothened receptor; Binding kinetics; TAK-441; Vismodegib; Cyclopamine; D473H
Keywords: سیکلوپامین; Cyclopamine; Lutetium-177; Lipid emulsion; Micelles; Radiation enhancement;
Keywords: سیکلوپامین; Hedgehog; Cyclopamine; Smoothened agonist (SAG); Purmorphamine (PMA); Gli1; Gli3; Dorsal aorta;
Keywords: سیکلوپامین; Subarachnoid hemorrhage; Sonic hedgehog pathway; Cyclopamine; Early brain injury;
Keywords: سیکلوپامین; Hedgehog signaling; Cyclopamine; Dendritic cells; Advanced cancer; Hypoxia;
Sinomenine reduces growth and metastasis of breast cancer cells and improves the survival of tumor-bearing mice through suppressing the SHh pathway
Keywords: سیکلوپامین; Hh; Hedgehog; SMO; smoothened; Ptch1; Patched 1 receptor 1; SHh; sonic hedgehog; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; EMT; epithelial-mesenchymal transition; qPCR; quantitative polymerase chain reaction; IHC; hematoxylin
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold
Keywords: سیکلوپامین; Biomimetic materials; Liver stem cells; Bioengineering; Organogenesis; iPSC; induced pluripotent stem cell; IH; iPSC derived hepatic progenitors; FDA; food and drug administration; TGFβ; transforming growth factor beta; 3D; three-dimensional; ICC; invert
Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities
Keywords: سیکلوپامین; Asp; aspartate; BisII; bisindolylmaleimideII; CYC; cyclopamine; MTT; thiazolyl blue tetrazolium bromide; PKCδ; PKC delta; PMA; phorbol 12-myristate 13-acetate; SHH; sonic hedgehog; Smo; Smoothened; STP; straurosporine; TfR,; transferrin receptor; UCPH; U
Cyclopamine bioactivity by extraction method from Veratrum californicum
Keywords: سیکلوپامین; Steroidal alkaloids; Hedgehog signaling; Veratrum californicum; Cyclopamine;
Generation of highly enriched V2a interneurons from mouse embryonic stem cells
Keywords: سیکلوپامین; CPG; central pattern generator; Cyc; cyclopamine; DAPT; N-{N-(3,5-difluorophenacetyl-L-alanyl))-(S)-phenylglycine-t-butyl-ester; EB; embryoid body; EPSC; excitatory post synaptic current; ESC; embryonic stem cell; FACS; Fluorescence-activated cell sorting
Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis
Keywords: سیکلوپامین; MS; multiple sclerosis; CNS; central nervous system; S1P; sphingosine 1-phosphate; BBB; blood-brain barrier; OPC; oligodendrocyte progenitor cell; Shh; sonic hedgehog; Smo; smoothened; EAE; experimental autoimmune encephalomyelitis; PLP; myelin proteoli
Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
Keywords: سیکلوپامین; Sonic hedgehog; ZRS; Polydactyly; HOXA13; Cyclopamine; SAG;
HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects
Keywords: سیکلوپامین; N-(2-hydroxypropyl)methacrylamide (HPMA); Combination therapy; Cancer stem/progenitor cells; Cyclopamine; Docetaxel;
SP8 regulates signaling centers during craniofacial development
Keywords: سیکلوپامین; Craniofacial development; Neural crest; Anterior neural ridge; SP8; FGF8; FGF17; Cyclopamine; Olfactory pits; Signaling center;
The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes
Keywords: سیکلوپامین; Indian hedgehog; Ihh signal; PTHrP; Cyclopamine; Chondrocytes
Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect
Keywords: سیکلوپامین; Cyclopamine; Jervine; Apoptosis; Cyclooxygenase-2; Erythroleukemia
A convenient and efficient one-pot conversion of peimisine into cyclopamine
Keywords: سیکلوپامین; Cyclopamine; Peimisine; Chemical conversion; Bamford-Stevens reaction;
Development of a monoclonal antibody-based ELISA for the hedgehog inhibitors cyclopamine and KAAD-cyclopamine
Keywords: سیکلوپامین; Cyclopamine; Cancer; Enzyme-linked immunoassay; Hedgehog pathway
Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke
Keywords: سیکلوپامین; Middle cerebral artery occlusion; Cyclopamine; Glioma-associated oncogene homolog 1; Patched-1; Superoxide dismutase 1;
Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells
Keywords: سیکلوپامین; Prostate cancer; Cancer stem cells; HPMA; Hedgehog; Cyclopamine
Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine
Keywords: سیکلوپامین; Hedgehog; Zebrafish; Cyclopamine; Hspb11; SANT-2; GANT-61
Internalization and induction of antioxidant messages by microvesicles contribute to the antiapoptotic effects on human endothelial cells
Keywords: سیکلوپامین; Act D; actinomycin D; ATP; adenosine triphosphate; BSA; bovine serum albumin; CMH; 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine; Cu/Zn-SOD; copper/zinc superoxide dismutase; CUR61414; N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazi
Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish
Keywords: سیکلوپامین; Zebrafish; Heart; Endocardium; Hedgehog; Fibronectin; NFATc1; Endoderm; Cyclopamine; Smoothened; Notochord;
Indian hedgehog signaling is required for proper formation, maintenance and migration of Xenopus neural crest
Keywords: سیکلوپامین; Neural crest; Specification; Maintenance; Hedgehog; Cell migration; Cyclopamine
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor
Keywords: سیکلوپامین; Sonic Hedgehog pathway; Cyclopamine; Hydroformylation; Cyclohydrocarbonylation
Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors
Keywords: سیکلوپامین; Cyclopamine; Steroidal alkaloid; Cancer chemotherapy; Hedgehog signaling; Structure-activity relationships;
Research ArticleEpithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
Keywords: سیکلوپامین; ALDH; aldehyde dehydrogenase; APC; allophycocyanin; CPM; cyclopamine; CSCs; cancer stem cells; DAPI; 4â²,6-diamidino-2-phenylindole; EMT; epithelial mesenchymal transition; FACS; fluorescence-activated cell sorting; FITC; fluorescein isothiocyanate; GAPD
Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells
Keywords: سیکلوپامین; Myeloid leukemia cell; Differentiation; Cyclopamine; CD44; Eosinophil; Luxol-fast-blue staining
Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells
Keywords: سیکلوپامین; Neuroblastoma; Sonic hedgehog; Cyclopamine; CD133; CD15
Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma
Keywords: سیکلوپامین; Cyclopamine; Prodrug; Chemotherapy; Glioblastoma; Glucuronide
Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album
Keywords: سیکلوپامین; Hedgehog; Dihydroveratramine; Cyclopamine; Veratrum album; LC–MS; NMR
Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening
Keywords: سیکلوپامین; Hh, Hedgehog; HPE, holoprosencephaly; CLP, cleft lip and palate; Ptc1, Patched; Smo, Smoothened; Shh, Sonic Hedgehog; MEF, mouse embryonic fibroblastsHedgehog signaling; Cyclopamine; Small molecule screening; Birth defects
Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified
Keywords: سیکلوپامین; Cyclopamine; Hedgehog; Isomerization; NMR; LC-MS;
Gli2 Expression and Human Bladder Transitional Carcinoma Cell Invasiveness
Keywords: سیکلوپامین; urinary bladder neoplasms; carcinoma, transitional cell; gene expression; cyclopamine; Gli2 protein; EMT; epithelial-to-mesenchymal transition; EtOH; ethanol; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Hh; hedgehog; IHH; Indian Hh; Ptch; Patched; qP
Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition
Keywords: سیکلوپامین; Cortical neurons; Cyclopamine; Huntington's disease; 3-Nitropropionic acid; Soluble erythropoietin receptor
The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches
Keywords: سیکلوپامین; Tumor initiating cells (TICs); Cancer stem cells (CSCs); Breast cancer; Tumor initiating cell-directed therapies; Sulphoraphane; Perfosine; Cyclopamine; Repertaxin; Early relapse; Late recurrence
Modulators of the hedgehog signaling pathway
Keywords: سیکلوپامین; Antitumor agents; Cyclopamine; Hedgehog signaling; AKT; protein kinase B; ALP; alkaline phosphatase; BCC; basal cell carcinoma; BCR-ABL1; breakpoint cluster region-Abelson murine leukemia; β-TrCP; β-transducin repeat containing protein; BMP; bone morpho
Autocrine and paracrine Shh signaling are necessary for tooth morphogenesis, but not tooth replacement in snakes and lizards (Squamata)
Keywords: سیکلوپامین; Reptile; Evolution; Development; Odontogenesis; Sonic hedgehog; Patched1; Wnt; Vestigial organ; Cell proliferation; Cell survival; Mitogen; Cyclopamine; Eublepharis macularius; Pogona vitticeps; Python regius; Stellate reticulum; Dental lamina; Succession
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer
Keywords: سیکلوپامین; Hedgehog signaling; Pancreatic cancer; Mechanism; Anticancer treatment; Cyclopamine
Blocking hedgehog signaling after ablation of the dorsal neural tube allows regeneration of the cardiac neural crest and rescue of outflow tract septation
Keywords: سیکلوپامین; Cardiac neural crest; Arterial pole; Neural tube; Cyclopamine; Sonic hedgehog; Regeneration;
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
Keywords: سیکلوپامین; SANT-2; Cyclopamine; Hedgehog; Medaka; Cyclopia
A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary
Keywords: سیکلوپامین; Adenohypophysis; Corticotropes; Cyclopamine; Gonadotropes; Lactotropes; Melanotropes; Pars distalis; Pars intermedia; Somatotropes; Thyrotropes;
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent
Keywords: سیکلوپامین; Primordial germ cell; Zebrafish; Hedgehog signaling; Smoothened; Cyclopamine;
Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells
Keywords: سیکلوپامین; Hedgehog; PC-3 cells; Autocrine; Prostate cancer; Gli; Luciferase; Cyclopamine
Synthesis and anticancer activity studies of cyclopamine derivatives
Keywords: سیکلوپامین; Cyclopamine; Carbohydrates; Hedgehog pathway; Bioconjugates