کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138068 1087867 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells
چکیده انگلیسی

Cyclopamine, a plant-derived steroidal alkaloid, inhibits the hedgehog (Hh) signaling pathway by antagonizing Smoothened. This drug can induce the differentiation of myeloid leukemia cell lines and acute myeloid leukemia (AML) cells in primary culture. The treated cells were stained with Luxol-fast-blue, which is specific for eosinophilic granules. Ligation of CD44 with some specific monoclonal antibodies can reverse the differentiation of AML cells. Combined treatment with cyclopamine and a monoclonal antibody to ligate CD44 more than additively induced the differentiation of HL-60 cells. These results may provide useful information for the development of a CD44-targeted therapy in AML.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 35, Issue 5, May 2011, Pages 638–645
نویسندگان
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