A convenient and efficient one-pot conversion of peimisine into cyclopamine

A convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The key steps involve one-pot hydrazination and subsequent Bamford-Stevens reaction. The mild reaction conditions, high overall yield as well as an easy purification indicate this process can potentially be used for the scale-up preparation of cyclopamine.

A convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The mild reaction conditions, high overall yield as well as an easy purification process give benefit for the scale-up preparation of cyclopamine.107