کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399667 | 1501198 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines](/preview/png/1399667.png)
چکیده انگلیسی
5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2–10. Furthermore, the preparation of sugar hydrazone derivatives 11a,b, 12a,b and their annelated C-nucleosides 13a,b was described. Some of the prepared products revealed promising antiviral activity against herpes simplex virus type-1 (HSV-1) in comparison to Acyclovir as a control.
Pyrazolo[3,4-d]pyrimidine derivatives are interesting compounds with diverse chemical properties and antiviral activities. Herein, the synthesis and antiviral evaluation of some new pyrazoles and pyrazolo[3,4-d]pyrimidines are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 8, August 2009, Pages 3285–3292
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 8, August 2009, Pages 3285–3292
نویسندگان
Aymn E. Rashad, Mohamed I. Hegab, Randa E. Abdel-Megeid, Nahed Fathalla, Farouk M.E. Abdel-Megeid,