کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399680 | 1501198 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and structure analysis of cyclodehydration product of piroxicam: A metabolite detected in dogs and monkeys
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and structure analysis of cyclodehydration product of piroxicam: A metabolite detected in dogs and monkeys Synthesis and structure analysis of cyclodehydration product of piroxicam: A metabolite detected in dogs and monkeys](/preview/png/1399680.png)
چکیده انگلیسی
We report here a novel synthesis of 6-methyl-6H-7-oxopyrido[1,2-a]pyrimido[5,4-c]-1,2-benzothiazine-5,5-dioxide or cyclodehydration product of piroxicam, a metabolite detected in dogs and monkeys that was synthesized in 6% yield earlier. The reaction of benzoyl chloride with piroxicam in the presence of triethylamine afforded the piroxicam metabolite in good yield. A comparison of spectral data of the synthesized compound with the reported values remained inconclusive. The structure of the compound was confirmed unambiguously by single-crystal X-ray analysis.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 8, August 2009, Pages 3368–3371
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 8, August 2009, Pages 3368–3371
نویسندگان
Sarbani Pal, P. Bindu, P.K. Dubey, Santu Chakraborty, Alok Kumar Mukherjee,