کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399695 | 1501210 | 2008 | 9 صفحه PDF | دانلود رایگان |
Some 1-[4-(9-benzyl-2-phenyl-9H-purin-6-ylamino)-phenyl]-3-phenyl-urea derivatives and some 1-[4-(9-benzyl-2-phenyl-9H-8-azapurin-6-ylamino)-phenyl]-3-phenyl-urea derivatives were synthesised and evaluated for their interaction with adenosine receptors. It was found that some of these compounds can act as positive enhancers of agonist and antagonist radioligands for the A2A adenosine receptors. This evidence was also strengthened by functional data. Other compounds can act as negative modulators.Furthermore these compounds show inhibitory properties for A1 and A3 adenosine receptors.
It was found that some of these compounds can act as positive enhancers of agonist and antagonist radioligands for A2A adenosine receptors; other compounds can act as negative modulators.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 8, August 2008, Pages 1639–1647