کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399840 | 1501216 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation–π-stacking interactions. Guanidinium ions can be involved in cation–π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.
A Series of guanidino-alkyl-ribitol derivatives were synthesized, showing moderate to good inhibiting activity towards the nucleoside hydrolase enzyme isolated from Trypanosoma vivax.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 2, February 2008, Pages 315–326
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 2, February 2008, Pages 315–326
نویسندگان
A. Goeminne, M. McNaughton, G. Bal, G. Surpateanu, P. Van Der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, K. Augustyns,