کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399840 1501216 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors
چکیده انگلیسی

Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation–π-stacking interactions. Guanidinium ions can be involved in cation–π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.

A Series of guanidino-alkyl-ribitol derivatives were synthesized, showing moderate to good inhibiting activity towards the nucleoside hydrolase enzyme isolated from Trypanosoma vivax.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 2, February 2008, Pages 315–326
نویسندگان
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