Biological studies of new organotin(IV) complexes of thioamide ligands

New organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzothiazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C6H5)3Sn(mbzt)] (1), [(C6H5)3Sn(cmbzt)] (3) and [(C6H5)2Sn(cmbzt)2] (4), together with the already known [(C6H5)3Sn(mbzo)] (2), [(n-C4H9)2Sn(cmbzt)2] (5) and [(CH3)2Sn(cmbzt)2] (6) were used to study their influence on the peroxidation of oleic acid. The influence of complexes (3)–(6) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes (1)–(6) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds (1)–(6) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells.

Organotin(IV) complexes with thioamides were studied for their promotion upon the peroxidation of oleic acid and their inhibition towards the peroxidation of linoleic acid by enzyme lipoxygenase. Also, they were tested for in vitro cytotoxicity against sarcoma cancer cells.Figure optionsDownload as PowerPoint slide