QSAR analysis of PPAR-γ agonists as anti-diabetic agents

QSAR studies have been performed on some PPAR-γ agonist thiazolidinediones to identify the essential structural and physico-chemical features for their agonistic activity. The predicted activities by the developed models were in good accordance with the observed activities. The developed QSAR model was validated using a test set of five compounds and good predictive r2 values of generated equations confirm the robustness of the model