کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1440443 1509370 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conjugation of methotrexate onto dedoped Fe3O4/PPy nanospheres to produce magnetic targeting drug with controlled drug release and targeting specificity for HeLa cells
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Conjugation of methotrexate onto dedoped Fe3O4/PPy nanospheres to produce magnetic targeting drug with controlled drug release and targeting specificity for HeLa cells
چکیده انگلیسی


• Fluorescent Fe3O4/PPy nanospheres with average size of 100 nm are prepared.
• The Fe3O4/PPy nanospheres possess superparamagnetism and high magnetization.
• Facile construction of fluorescent Fe3O4/PPy/methotrexate targeting drug is achieved.
• The magnetic targeting drug exhibits controllable drug release.
• The magnetic targeting drug shows specific targeting ability to HeLa cells

sMagnetic composite nanospheres carrying amino groups have attracted much interest due to their potential applications in the fields of catalysis, sensor, water purification, enzyme immobilization, DNA extraction, and drug delivery. In this paper, dedoped Fe3O4/polypyrrole (PPy) nanospheres with core–shell structure, high magnetization, superparamagnetism, and size meeting the demand of biorelated applications in vivo have been achieved by an in situ polymerization approach. The amount of the surface amino groups of Fe3O4/PPy is greatly enhanced by dedoping treatment due to liberation of the amino groups ever sheltered by the dopants, a situation that is responsible for facile conjugation of fluorescein and methotrexate (MTX) onto the magnetic composite through the EDC/NHS coupling chemistry to produce the desirable fluorescent Fe3O4/PPy/MTX targeting drug with a high MTX loading of ca. 109 μg mg−1. The as-obtained magnetic targeting drug exhibits controlled drug release, enhanced intracellular drug retention, and specific targeting ability to HeLa cells, presenting a promising candidate for treatment of cancer cells overexpressing folate receptors.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Synthetic Metals - Volume 207, September 2015, Pages 18–25
نویسندگان
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