Synthesis, characterization and drug delivery activity of poly(anthranilicacid) based triblock copolymer

• Processability of poly(anthranilicacid) was improved by introducing the PCL and PTHF units.
• The rigidity of PAA was reduced with the increase of solubility in common organic solvents.
• The drug delivery efficiency was improved.
• The fluorescence emission intensity was increased.

The poly(tetrahydrofuran) (PTHF) grafted poly(caprolactone)-poly(anthranilicacid)-poly(caprolactone) (PCL-PAA-PCL) co-polymer system was synthesized by using a prepolymer under nitrogen atmosphere in the presence of a stannous octoate catalyst. The [M0/I0] was maintained at 100. The polymers at each stage was characterized by various analytical techniques like FTIR spectroscopy, NMR spectroscopy, UV–visible spectroscopy, fluorescence spectroscopy, cyclic voltammetry, DSC, TGA, conductivity, FESEM, solubility test, cytotoxicity and drug release study. The results obtained here in the present investigation are critically compared with the literature values.

The DSC thermogram of PAA and its block copolymers are given here. After the introduction of semi-crystalline PCL only the diblock copolymer exhibits a melting peak corresponding to the PCL. After the introduction of PTHF units the melting temperature was suppressed due to the hydrophilic nature of PTHF.Figure optionsDownload as PowerPoint slide