کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
144116 | 438922 | 2016 | 6 صفحه PDF | دانلود رایگان |
• The supersaturated state of curcumin (CUR) in water was maintained for at least 24 h.
• The ternary system exhibited a 2600-fold higher solubility than untreated CUR.
• An amorphous formulation in the ternary system was formed via an evaporation process.
• The hydrolytic stability of CUR in the ternary system was improved.
We developed a formulation for increasing the water solubility of curcumin (CUR). The new formulation also protected CUR from hydrolytic degradation. A ternary system of CUR/α-glucosyl hesperidin (hesperidin-G)/polyvinylpyrrolidone (PVP) K-30 was prepared by the solvent evaporation method. Although the binary sample of CUR/hesperidin-G showed increased solubility, the effect disappeared within a few hours of storage in aqueous media. In contrast, the ternary system of CUR/hesperidin-G/PVP K-30 (1:10:5, weight ratio) exhibited a long-lasting solubility increase. This supersaturated CUR solution remained stable even after 24 h, as shown by the 2600-fold increase in solubility compared with untreated CUR. The stability of CUR to hydrolytic degradation under alkaline conditions was improved dramatically by adding hesperidin-G and PVP K-30, whereas untreated CUR completely decomposed after a few minutes. The solubilizing effect may arise from the formation of an amorphous solid dispersion, including CUR, and from complex formation between CUR, hesperidin-G, and PVP K-30 in aqueous media. The complex may also protect CUR from hydrolytic degradation.
Figure optionsDownload as PowerPoint slide
Journal: Advanced Powder Technology - Volume 27, Issue 2, March 2016, Pages 442–447