کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
144904 | 438954 | 2013 | 19 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Multi-dimensional mechanistic modeling of fluid bed granulation processes: An integrated approach Multi-dimensional mechanistic modeling of fluid bed granulation processes: An integrated approach](/preview/png/144904.png)
This paper is concerned with the integration of a heat and mass model with a population balance model of a fluid bed granulation process. The heat/mass model helps to track the liquid and porosity changes that occur within the granulation process due to simultaneous drying in the granulator. A mechanistic kernel proposed by [22] was used to model the aggregation process, which is a function of mechanistic properties such as liquid thickness and particle size. The model takes into account various mechanisms that significantly affect the granulation outcome, such as aggregation, drying/rewetting, and consolidation. Since these rate processes evolve dynamically, the aggregation kernel is updated periodically over time and for the first time, dynamically coupled with the heat/mass model to provide a more accurate qualitative description of granulation dynamics in a fluid-bed granulator.
Figure: Schematic of the algorithm for solving the coupled heat + mass balance and PBM using a mechanistic aggregation kernelFigure optionsDownload as PowerPoint slideHighlights
► An integrated multi-dimensional population balance model is developed.
► Qualitative model validation integrating key granulation mechanisms is performed.
► The effect of key process parameters on granulation dynamics is studied.
Journal: Advanced Powder Technology - Volume 24, Issue 1, January 2013, Pages 113–131