Preparation of calcium phosphate cement with an improved setting behavior

• Calcium phosphate cements (CPCs), which stay fluid at room temperature for a longer time and set promptly under physiological conditions, were developed.
• Gelatin coating on TeTCP or DCPD-containing powder component effectively controlled the setting behavior.
• Compressive strength of 41 MPa was attained.

In the aim of the development of a calcium phosphate cement (CPC) that allows a sufficiently long kneading time at room temperature while sets promptly at a physiological temperature, the powder components of a CPC of a TeTCP–α-TCP–DCPD system were coated with gelatin. The gelatin coating on TeTCP or DCPD-containing portion effectively retarded the setting reaction at 293 K while it did not hinder at 310 K, implying the possibility of CPC with an improved setting behavior. Compressive strength of 41 MPa was attained for a gelatin-coated CPC.