Modified MCM-41 as a drug delivery system for acetylsalicylic acid

• The modification of MCM-41 by amino, chloro and glycidoxy groups was studied.
• All prepared systems were used as a drug controlled delivery system of acetylsalicylic acid.
• The type of modification has a crucial effect on the release properties.
• The appropriate functional group (glycidoxy) is favorable for drug delivery.

The modification of prepared MCM-41 by different groups (amino, chloro and oxo) was studied. Prepared materials were treated by acetylsalicylic acid and hybrid materials were characterized, compared from the point of view of immobilized amount of active substance. The highest amount of acetylsalicylic acid was detected using methyl-tert- butyl ether as a solvent and MCM-41 without modification after 1 h (0.35 g per 1 g of the support) or MCM modified by amino group after 5 h (0.37 g per 1 g of the support) as a support. Using amino modified MCM, the longer treatment by acetylsalicylic acid converged to the equilibrium and after 24 h the immobilized amount was 0.3 g per 1 g. A dissolution in vitro study was carried out, comparing the stability of formed interactions. The slowest dissolution was detected using non-modified MCM-41 and oxo modified material.

Figure optionsDownload as PowerPoint slide