New versatile polydopamine coated functionalized magnetic nanoparticles

Polydopamine coated magnetite nanoparticles are functionalized with azido groups by reaction with 4-azidobutylamine. The resulting nanoparticles allow straight forward Cu-catalyzed “click”-reaction with alkynes. In this way practically interesting functions can be tethered to the nanoparticles as exemplified by introducing biotin, glucose, proline or dansyl. The nanoparticles exhibit superparamagnetic behavior.

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► Azido groups linked to polydopamine–magnetite nanoparticles provide magnetic nano-carriers.
► Biotin, dansyl, glucose and proline are fixed by CuAAC with alkynes via 1,2,3-triazole rings.
► Functionalized polydopamine–magnetite nanoparticles show superparamagnetic behavior.