Polyaniline–bismuth oxide nanocomposite sensor for quantification of anti-parkinson drug pramipexole in solubilized system

• PANI–Bi2O3 nanocomposite has been synthesized first time and effectively used for the electrochemical studies.
• PANI–Bi2O3/GCE modified sensors have a large surface area greatly enhancing the sensitivity of electroactive species.
• Modified sensor was successfully used for the detection of pramipexole utilizing enhancement effect of surfactant.
• The reported method showed very good stability as well as reproducibility for the voltammetric analysis of pramipexole.

In this study, a new sensor polyaniline–bismuth oxide (PANI–Bi2O3) nanocomposite has been fabricated and characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). SEM was used to provide information about the morphology of the PANI–Bi2O3 nanocomposite. Cyclic voltammetric studies of electroactive species i.e. K3Fe(CN)6 demonstrate almost reversible electrochemical behaviour, with diffusion controlled mass transfer process in the double layer region of the electrode. EIS studies revealed that PANI–Bi2O3/GCE having lower charge transfer resistance which leads to higher electrocatalytic activity. This modified electrode was successfully used for the detection of pramipexole in pharmaceutical formulation in sodium lauryl sulphate (SLS) in Britton Robinson (BR) buffer at pH 4.5. The ease of fabrication, excellent electrochemical performance and high electroactive surface area are the promising features of the fabricated sensor.

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