کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1531115 1512001 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioconjugated carbon nanotubes for targeting cancer biomarkers
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد مواد الکترونیکی، نوری و مغناطیسی
پیش نمایش صفحه اول مقاله
Bioconjugated carbon nanotubes for targeting cancer biomarkers
چکیده انگلیسی

This paper presents real-time detection of breast cancer cells through label-free protein biosensors based on antibody-conjugated carbon nanotube field effect transistors (CNTFETs). Both insulin-like growth factor 1 receptor (IGF1R) specific and nonspecific monoclonal antibodies (mAbs) reduced the electrical conductance of the CNTFET devices. Subsequent application of human BT474 and MCF7 breast cancer cells resulted in an increase in the conductance only for the IGF1R-specific mAb-CNTFET devices. Furthermore, the MCF7 breast cancer cells produced a greater increase in device conductance compared to BT474 breast cancer cells. This could be attributed to the larger number of IGF1 receptors in MCF7 breast cancer cells compared to BT474 cancer cells. Nonspecific mAb-CNTFETs did not yield any change in the conductance of the devices due to application of BT474 and MCF7 breast cancer cells. These results therefore imply that specific binding between IGF1 receptor and its specific mAb results in a dramatic change in electrical conductance of CNTFET devices. Consequently, mAb-CNTFETs are very promising biosensor candidates to detect circulating cancer cells in blood samples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: B - Volume 153, Issues 1–3, 25 September 2008, Pages 83–87
نویسندگان
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